Our CEO and Scientific Head, Professor Klaus-Peter Adlassnig, acted as the Scientific Program Chair of the XXII International Conference on Medical Informatics Europe MIE 2009 that was held in Sarajevo, Bosnia and Herzegovina, from 30 August to 2 September 2009. The conference included 171 scientific oral and 21 poster presentations, 5 tutorials, 16 workshops, and 9 keynote lectures, and attracted about 400 participants from 38 different countries. The scientific topics presented there ranged from national and trans-national eHealth roadmaps, health information and electronic health record systems, systems interoperability and communication standards, medical terminology and ontology approaches, and social networks to Web, Web 2.0, and Semantic Web solutions for patients, health personnel, and researchers. Furthermore, they included quality assurance and usability of medical informatics systems, specific disease management and telemedicine systems, drug safety, clinical decision support and medical expert systems, clinical practice guidelines and protocols, as well as issues on privacy and security. Moreover, bioinformatics, biomedical modeling and simulation, medical imaging and visualization and, last but not least, learning and education through medical informatics systems were part of the included topic areas.