A first, small accuracy and impact study on Moni/Surveillance-ICU, our software for the early identification and continuous monitoring of hospital-acquired infections in intensive care units (ICUs), was carried out. The HELICS-based definitions of the various episodes of infection were evaluated by both human infection control experts and automated Moni/Surveillance-ICU computations. This was done for 99 patients with a total of 1007 patient days. Specificity was 100% and sensitivity 90.3%. There are still some data import and rule definition problems through non-digitizable medical data, but overall time savings for the medical specialists was almost 85% (a total of 70 h). To be presented at the 13^th World Congress on Medical and Health Informatics MEDINFO 2010, 12 to 15 September 2010, Cape Town, South Africa.